Hormones and Fat Distribution: Does Testosterone Therapy Help Older Women?
By Marcus Vance
Standard care has long relied on conventional estrogen-progesterone hormone replacement therapy (HRT) or dietary interventions alone. The 2026 UConn data establishes clear distinctions between conventional approaches and integrated androgen therapy across key physiological metrics.
| Biomarker / Clinical Metric | Diet & Caloric Deficit Only | Standard Estrogen-Only HRT | Targeted Testosterone Regimen |
|---|---|---|---|
| Visceral Fat Volume Change | -1.5% to -2.8% (often stalls) | -3.2% average reduction | -7.5% to -9.1% documented loss |
| Lean Muscle Mass Retention | Negative (muscle wasting common) | Neutral preservation | +2.1% to +3.4% lean mass increase |
| HOMA-IR (Insulin Sensitivity) | Marginal improvement (-4%) | Moderate stabilization (-9%) | Significant drop (-18% to -22%) |
| Resting Metabolic Rate (RMR) | Declines due to adaptive thermogenesis | Maintains baseline | Increases by 65, 110 kcal/day |
Marcus Vance is a cybersecurity auditor and technology writer dedicated to educating the public about online safety, data privacy regulations, enterprise security, and emerging cyber threats.
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